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Obesity is a one of the major but preventable global health crises that has been linked to major chronic illness and several cancers, with increased morbidity and mortality. Among the various cancers, breast, colorectal, endometrial, esophageal, pancreatic, renal, hepatic, stomach, gallbladder, ovarian, and thyroid cancer, as well as multiple myeloma and meningioma, are strongly associated with obesity. The underlying mechanism of obesity causing cancer is incompletely understood and involves adipokines, inflammation, an altered extracellular matrix, altered fatty acid metabolism, and the secretion of insulin-like growth factors and estrogen. Weight-reducing strategies in obesity-associated cancers are important interventions as a component of cancer care in reducing cancer-specific and overall mortality in cancer survivors with excess body weight. Regular exercise and diet, in conjunction with behavior therapy, are the primary elements of weight reducing strategies. More data are needed regarding the efficacy and safety of pharmacologic and surgical interventions as a major weight reduction strategy in cancer survivors.A
